Klario for health professionals

A novel, first-in-class hypo recovery drink, designed to deliver complete recovery for your patients.

Most clinicians visiting this page already know Klario as a new option for self-managed hypoglycaemia recovery. This section summarises what is new and clinically relevant, so you can confidently advise patients on when Klario may be appropriate alongside existing guidance.

KEY CLINICAL MESSAGES

Klario: clinical summary

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Klario is a novel hypo recovery drink that combines the recommended 15 g of fast-acting carbohydrate with additional energy sources - β-hydroxybutyrate (BHB) and lactate.
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In a 12-week randomised clinical study (>1,000 hypo episodes) led by UK diabetes specialist Prof. Russell Jones, Klario significantly improved outcomes versus standard glucose-only products.
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Klario users showed improved glycaemic outcomes, including significantly better post-hypo time-in-range and a 27% reduction in recurrent hypoglycaemic events.
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Recovery from brain fog and the "hypo hangover", as well as return to daily activities and work, was significantly faster with Klario compared to standard glucose-only products.
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Experimental evidence suggests BHB, may also support long-term neuronal health through anti-oxidant and anti-inflammatory actions.

Study at a glance

  • Design: RCT
  • Duration: 12 weeks
  • Population: Adults with T1D
  • PI: Prof. D Russell-Jones

Key Findings:

  • 27% ↓ recurrent hypos
  • Improved post-hypo TIR
  • Statistically significant improvements in patient reported outcomes
READ A SUMMARY

"a potential new standard of care"

- Prof. Louis Monnier (University of Montpellier) & Prof. David Owens (Swansea University)

Patients say Klario makes a real difference

Real-world patient experiences from clinical trial participants, showing how measured clinical gains with Klario translate into everyday quality of life improvements that your patients care about most.

The science behind Klario

How Klario works: the brain energy bottleneck

Standard glucose corrects blood sugar, but the brain often remains under-fuelled after a hypo. Utilisation of glucose by neurons may be limited by inhibition of glycolysis due to NAD+ depletion.

Klario combines 15 g of fast-acting carbohydrates with BHB and lactate - adaptive energy sources which cross the blood brain barrier to provide efficient energy delivery when glycolysis is compromised.

Mechanism overview (3 min read)

Proven clinical outcomes with Klario

In the 12-week randomised study, Klario improved post-hypo time-in-range and reduced recurrent hypoglycaemia by 27% compared with standard glucose-only products.

Statistically significant improvements in speed of symptom relief, resolution of after-effects (e.g. fatigue and brain fog) were also recorded, supporting a more complete return to normal function.

Read the full paper

Beyond the hypo: potential brain benefits

BHB has been widely studied as an alternative fuel for the brain - shown to support mitochondrial function, activate anti-inflammatory and anti-oxidative pathways and promote neuronal survival.

Klario's advanced combination formula is designed with these broader benefits in mind, while remaining a practical, self-care solution for everyday hypos.

Read more about BHB and the brain (3-min read)

Why Klario matters

Hypoglycaemia remains a significant burden in insulin-treated diabetes - people with type 1 diabetes experience 100-200 episodes per year. Glucose-only treatments frequently result in suboptimal outcomes:

  • Persistent "hypo hangover" after standard treatments with delayed return to normal cognitive function
  • Recurrent events within hours of initial treatment (a "glucose rollercoaster")
  • Impact on daily activities - work, driving, learning - with some studies reporting up to 10 hours lost per episode
  • Neuronal oxidative stress and inflammation following glucose reperfusion
  1. Frier, et al. Diabet Med. 2016;33(8):1125-32.
  2. Zammitt, et al. Diabetes. 2008;57(3):732-6.
  3. Hansen KW, Bibby BM. J Diabetes Sci Technol. 2024;18(6):1392-8.
  4. Brod, et al. Value Health. 2011;14(5):665-71.
  5. Suh, et al. J Clin Invest. 2007;117(4):910-8.